Hydrochloric Acid → HCID 66797230, compound

HRID 1487771Notes

Reaction equation

HRID 1487771 reaction equation
[ClH:1].O1CCOCC1.[F:8][C:9]1[CH:10]=[C:11]([CH:37]=[CH:38][CH:39]=1)[O:12][CH2:13][CH:14]1[CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16][N:15]1[C:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=1)=[O:28]>CO>[ClH:36].[ClH:1].[F:8][C:9]1[CH:10]=[C:11]([CH:37]=[CH:38][CH:39]=1)[O:12][CH2:13][CH:14]1[CH2:19][NH:18][CH2:17][CH2:16][N:15]1[C:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=1)=[O:28]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59671572HCID 59671572, compound

Product 1

HCID 66797230HCID 66797230, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4 M HCl in 1,4-dioxane (6 mL, 24 mmol) was added to a solution of 4-tert-butyl 1-(4-chlorophenyl) 2-((3-fluorophenoxy)methyl)piperazine-1,4-dicarboxylate (38.3 mg, 0.082 mmol) in MeOH (1 mL). After 1 h, the reaction mixture was concentrated under reduced pressure, yielding 32.9 mg (99%) of the desired product as a white solid. LC-MS: RT=5.83 min, [M+H]+=365.1.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e2842cdd6f21498389247e7e33d27543
Source dataset
uspto-grants-2016_08
Patent number
US09428522B2

Reaction notes

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