反应详情

温度

55 °C

Into a 50-mL round-bottom flask, were placed methyl 5-(2,4-dimethyl-1H-imidazol-5-yl)-2,4-dimethylbenzoate (compound 1.7, 300 mg, 1.16 mmol) and sodium hydroxide (465 mg, 11.6 mmol) in methanol (20 mL) and H2O (5 mL). The resulting solution was stirred at 55° C. for 4 h, then after cooling to room temperature, aqueous HCl (2 M) was added to adjust the pH to 5. The resulting mixture was concentrated under reduced pressure and the residue was dissolved in methanol (5 mL). The solids were removed by filtration and the filtrate was concentrated under reduced pressure to yield the title compound as a light yellow solid (280 mg, crude), which was used in the next step without further purification.

1. customInto a 50-mL round-bottom flask, were placed
2. temperatureafter cooling to room temperature
3. concentrationThe resulting mixture was concentrated under reduced pressure
4. dissolutionthe residue was dissolved in methanol (5 mL)
5. customThe solids were removed by filtration
6. concentrationthe filtrate was concentrated under reduced pressure