Hydrochloric Acid → HCID 178494679, compound

HRID 1487878Notes

Reaction equation

HRID 1487878 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([CH2:18][O:19][CH3:20])[NH:5][C:6]=1[C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][C:16]=1[CH3:17])[C:10]([O:12]C)=[O:11].[OH-].[Na+].Cl>CO.O>[Cl:1][C:2]1[N:3]=[C:4]([CH2:18][O:19][CH3:20])[NH:5][C:6]=1[C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][C:16]=1[CH3:17])[C:10]([OH:12])=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178494680HCID 178494680, compound2×

Product 1

HCID 178494679HCID 178494679, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Into a 50-mL round-bottom flask, which was purged and maintained with an inert atmosphere of nitrogen, was added methyl 3-(4-chloro-2-(methoxymethyl)-1H-imidazol-5-yl)-4-methylbenzoate (compound 27.4, 50 mg, 0.19 mmol) and sodium hydroxide (31 mg, 0.76 mmol) in methanol/water (3 mL/3 mL). The resulting solution was stirred for 12 hours at room temperature. The pH of the solution was adjusted to 1-2 with hydrogen chloride (6 M), then concentrated under reduced pressure to yield 150 mg (crude) of the title compound as the HCl salt as white solid.

Workup

  1. customInto a 50-mL round-bottom flask, which was purged
  2. temperaturemaintained with an inert atmosphere of nitrogen
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-1988de8ba2224c58b334e7acaab889c4
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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