Tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate → Tert-butyl 4-([1,2,4]triazolo[4,3-a]pyridin-7-yl)piperidine-1-carboxylate

HRID 1487897Notes

Reaction equation

HRID 1487897 reaction equation
C(C1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#N.BrC1C=C[N:26]2[CH:29]=[N:30][N:31]=C2C=1>>[N:31]1[N:30]=[CH:29][N:26]2[CH:4]=[CH:5][C:6]([CH:9]3[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:16])[CH2:13][CH2:14]3)=[CH:7][C:8]=12

Participants

3

Reactant 2

HCID 22492960Tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylateHCID 231159667-Bromo-[1,2,4]triazolo[4,3-a]pyridine2×

Product 1

HCID 90066679Tert-butyl 4-([1,2,4]triazolo[4,3-a]pyridin-7-yl)piperidine-1-carboxylate

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 1.1, except 7-bromo-[1,2,4]triazolo[4,3-a]pyridine (compound 41.2) was used in place of 4-bromobenzonitrile. m/z (ES+) 303 (M+H)+.

Sources & evidence

ORD record
ord-408153a5fa5f40138da2fc241cad9777
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

Loading…