反应详情

Into a 100-mL round-bottom flask, was placed a solution of sodium sulfite (11.3 g, 89.7 mmol) in H2O/EtOH (30/15 mL). 2-Cyclopropyl-4,5-diiodo-1H-imidazole (compound 44.2, 3.8 g, 10.6 mmol) was added and the resulting solution was heated at reflux overnight. The reaction was cooled and the volatiles were removed under reduced pressure. The solids were collected by filtration to yield 1.8 g (73%) of the title compound as a light brown solid.

1. customInto a 100-mL round-bottom flask, was placed
2. temperaturethe resulting solution was heated
3. temperatureat reflux overnight
4. temperatureThe reaction was cooled
5. customthe volatiles were removed under reduced pressure
6. filtrationThe solids were collected by filtration