4-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1) → 3-Chloro-7-(piperidin-4-yl)imidazo[1,5-a]pyridine hydrochloride

HRID 1487936Notes

Reaction equation

HRID 1487936 reaction equation
Cl.N1CCC(C2C=CC(C#N)=CC=2)CC1.[Cl:16][C:17]1[N:21]2[CH:22]=[CH:23][C:24]([CH:26]3[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]3)=[CH:25][C:20]2=[CH:19][N:18]=1.C(C1C=CC(C2CCN(C(OC(C)(C)C)=O)CC2)=CC=1)#N>>[ClH:16].[Cl:16][C:17]1[N:21]2[CH:22]=[CH:23][C:24]([CH:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)=[CH:25][C:20]2=[CH:19][N:18]=1

Participants

4

Reactant 3

HCID 193916184-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)HCID 22492960Tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylateHCID 90029531Tert-butyl 4-(3-chloroimidazo[1,5-a]pyridin-7-yl)piperidine-1-carboxylate2×

Product 1

HCID 1182508793-Chloro-7-(piperidin-4-yl)imidazo[1,5-a]pyridine hydrochloride

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 1.2, except tert-butyl 4-(3-chloroimidazo[1,5-a]pyridin-7-yl)piperidine-1-carboxylate (compound 68.2) was used in place of tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate (compound 1.1) to yield the title compound as a yellow solid.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-09947d91a2a241f48084a96503534fd4
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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