HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Bromophenylethynyl)trimethylsilane → Tert-butyl 4-(4-((trimethylsilyl)ethynyl)phenyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Bromophenylethynyl)trimethylsilane | HCID 4226980 | — |
| Reactant | tert-butyl 4-(1H-indazol-5-yl)piperidine-1-carboxylate | HCID 49760224 | — |
| Product | Tert-butyl 4-(4-((trimethylsilyl)ethynyl)phenyl)piperidine-1-carboxylate | HCID 59805220 | 67% |
Reaction Steps
The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 62.4, except ((4-bromophenyl)ethynyl)trimethylsilane (compound 76.1, 850 mg, 3.36 mmol) was used in place of 5-bromo-1H-indazole to yield the title compound as a yellow oil (0.80 g, 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428502B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-fb90edc3c8714951af9a4810433690d1 |
| Source note | uspto-grants-2016_08 |