Methyl 4-cyclopropyl-2-methyl-5-(5-methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)benzoate → Methyl 4-cyclobutyl-2-methyl-5-(5-methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)benzoate

HRID 1487973Notes

Reaction equation

HRID 1487973 reaction equation
[CH:1]1([C:4]2[C:13]([C:14]3[NH:23][C:17]4[CH2:18][N:19]([CH3:22])[CH2:20][CH2:21][C:16]=4[N:15]=3)=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([CH3:24])[CH:5]=2)[CH2:3][CH2:2]1.[CH:25]1(C2C(C=O)=CC(C(OC)=O)=C(C)C=2)CCC1.C1(C2C(C=O)=CC(C(OC)=O)=C(C)C=2)CC1>>[CH:1]1([C:4]2[C:13]([C:14]3[NH:23][C:17]4[CH2:18][N:19]([CH3:22])[CH2:20][CH2:21][C:16]=4[N:15]=3)=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([CH3:24])[CH:5]=2)[CH2:3][CH2:25][CH2:2]1

Participants

4

Reactant 3

HCID 90020876Methyl 4-cyclopropyl-2-methyl-5-(5-methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)benzoateHCID 90021238Methyl 4-cyclopropyl-5-formyl-2-methylbenzoateHCID 90021669Methyl 4-cyclobutyl-5-formyl-2-methylbenzoate2×

Product 1

HCID 90021589Methyl 4-cyclobutyl-2-methyl-5-(5-methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)benzoate

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 87.4, except methyl 4-cyclobutyl-5-formyl-2-methylbenzoate (compound 82.5) was used in place of methyl 4-cyclopropyl-5-formyl-2-methylbenzoate (compound 87.1).

Sources & evidence

ORD record
ord-e4263633a74c4e03834c0638e0275cfa
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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