Methyl 4-bromo-2-methylbenzoate → Methyl 4-fluoro-5-iodo-2-methylbenzoate

HRID 1487991Notes

Reaction equation

HRID 1487991 reaction equation
Br[C:2]1C=CC(C(OC)=O)=C(C)C=1.[F:13][C:14]1[C:22]([I:23])=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[C:16]([CH3:24])[CH:15]=1>>[F:13][C:14]1[C:22]([I:23])=[CH:21][C:17]([C:18]([O:20][CH3:2])=[O:19])=[C:16]([CH3:24])[CH:15]=1

Participants

3

Reactant 2

HCID 22031226Methyl 4-bromo-2-methylbenzoateHCID 900215604-Fluoro-5-iodo-2-methylbenzoic acid2×

Product 1

HCID 90021566Methyl 4-fluoro-5-iodo-2-methylbenzoate

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 6.1, except 4-fluoro-5-iodo-2-methylbenzoic acid (compound 101.1) was used in place of 4-bromo-2-methylbenzoic acid.

Sources & evidence

ORD record
ord-35a1c6b3b0604e92a31176c016fdbb19
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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