4-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1) → HCID 178425799, compound

HRID 1488023Notes

Reaction equation

HRID 1488023 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[C:11]1[NH:15][C:14]([CH:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[N:13][C:12]=1[CH3:22].CC1C=C(C)C(C2N=C(C3CCOCC3)NC=2C)=CC=1C(O)=O.Cl.[NH:47]1[CH2:52][CH2:51][CH:50]([C:53]2[CH:60]=[CH:59][C:56]([C:57]#[N:58])=[CH:55][CH:54]=2)[CH2:49][CH2:48]1.Cl.N1CC(C2C=CC(C#N)=CC=2)C1>>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:47]2[CH2:52][CH2:51][CH:50]([C:53]3[CH:60]=[CH:59][C:56]([C:57]#[N:58])=[CH:55][CH:54]=3)[CH2:49][CH2:48]2)=[O:7])=[CH:4][C:3]=1[C:11]1[NH:15][C:14]([CH:16]2[CH2:17][CH2:18][O:19][CH2:20][CH2:21]2)=[N:13][C:12]=1[CH3:22]

Participants

5

Reactant 4

HCID 193916184-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)2×HCID 552549914-(Azetidin-3-yl)benzonitrile hydrochlorideHCID 900299762,4-Dimethyl-5-(4-methyl-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)benzoic acidHCID 178425884HCID 178425884, compound2×

Product 1

HCID 178425799HCID 178425799, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 164, except 4-methyl-3-(4-methyl-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)benzoic acid (compound 168.1) was used in place of 2,4-dimethyl-5-(4-methyl-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)benzoic acid (compound 164.2) and 4-(piperidin-4-yl)benzonitrile hydrochloride (compound 1.2) was used in place of 4-(azetidin-3-yl)benzonitrile hydrochloride (compound 5.2) m/z (ES+) 469 (M+H)+.

Sources & evidence

ORD record
ord-a4627dcd1cb546e6aac7941c44ff7880
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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