Tetrahydro-4H-pyran-4-one → HCID 178425792, compound

HRID 1488073Notes

Reaction equation

HRID 1488073 reaction equation
[OH:1][C:2]1([C:6]2[NH:7][C:8]([C:12]3[CH:13]=[C:14]([CH:29]=[CH:30][C:31]=3[CH3:32])[C:15]([N:17]3[CH2:20][CH:19]([C:21]4[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=4)[CH2:18]3)=[O:16])=[C:9]([CH3:11])[N:10]=2)[CH2:5]OC1.[O:33]1[CH2:38]CC(=O)[CH2:35][CH2:34]1>>[OH:1][C:2]1([C:6]2[NH:7][C:8]([C:12]3[CH:13]=[C:14]([CH:29]=[CH:30][C:31]=3[CH3:32])[C:15]([N:17]3[CH2:18][CH:19]([C:21]4[CH:22]=[CH:23][C:24]([C:25]#[N:26])=[CH:27][CH:28]=4)[CH2:20]3)=[O:16])=[C:9]([CH3:11])[N:10]=2)[CH2:35][CH2:34][O:33][CH2:38][CH2:5]1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 178425793HCID 178425793, compound

Product 1

HCID 178425792HCID 178425792, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 192, except dihydro-2H-pyran-4(3H)-one was used in place of oxetan-3-one. m/z (ES+) 457 (M+H)+.

Sources & evidence

ORD record
ord-4347f50baf3a490e8adbd4e47fec67a2
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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