反应详情

温度

90 °C

Into a 250-mL round-bottom flask, was placed a solution of 4,5-diiodo-2-(methoxymethyl)-1H-imidazole (compound 230.3, 2 g, 5.50 mmol) in ethanol (40 mL). A solution of Na2SO3 (5.9 g, 46.83 mmol) in water (80 mL) was added to the reaction. The reaction mixture was stirred overnight at 90° C. The resulting mixture was concentrated under reduced pressure. The residue was extracted with 3×20 mL of dichloromethane and the organic layers combined and concentrated under reduced pressure. This resulted in 1 g (76%) of the title compounds as yellow oil.

1. customInto a 250-mL round-bottom flask, was placed
2. concentrationThe resulting mixture was concentrated under reduced pressure
3. extractionThe residue was extracted with 3×20 mL of dichloromethane
4. concentrationconcentrated under reduced pressure