HCID 178494681, compound → HCID 178424690, compound

HRID 1488114Notes

Reaction equation

HRID 1488114 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([CH2:19][O:20]C)[NH:5][C:6]=1[C:7]1[C:8]([CH3:18])=[CH:9][C:10]([CH3:17])=[C:11]([CH:16]=1)[C:12]([O:14]C)=[O:13]>Br>[Cl:1][C:2]1[N:3]=[C:4]([CH2:19][OH:20])[NH:5][C:6]=1[C:7]1[C:8]([CH3:18])=[CH:9][C:10]([CH3:17])=[C:11]([CH:16]=1)[C:12]([OH:14])=[O:13]

Participants

3

Reactant 1

HCID 178494681HCID 178494681, compound2×

Product 1

HCID 178424690HCID 178424690, compoundYield 59.4%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Conditions

Temperature
90 °C

Procedure

Into a 50-mL round-bottom flask, was placed a solution of methyl 5-(4-chloro-2-(methoxymethyl)-1H-imidazol-5-yl)-2,4-dimethylbenzoate (compound 230.5, 20 mg, 0.06 mmol) in HBr (5 mL, 40% in AcOH). The reaction mixture was stirred overnight at 90° C. The resulting mixture was concentrated under reduced pressure. This resulted in 10 mg (55%) of the title compound as a yellow crude solid.

Workup

  1. customInto a 50-mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a5a41ad08db44c28b87b83c900cf2d5a
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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