反应详情

Into a 100-mL round-bottom flask, was placed a solution of 1-benzyl-1H-pyrazol-4-ol (compound 244.2, 1.40 g, 8.04 mmol) in N,N-dimethylformamide (20 mL). Iodomethane (703 μL, 11.3 mmol) and Cs2CO3 (3.68 g, 11.3 mmol,) were added and the resulting mixture was stirred for 3 h at room temperature. The mixture was concentrated under reduced pressure, then diluted with EtOAc (200 mL). The mixture was washed with brine (3×80 mL), and the organic layer was dried (Na2SO4), filtered and concentrated under reduced pressure to obtain the title compound as a yellow oil (1.30 g, 86%).

1. customInto a 100-mL round-bottom flask, was placed
2. concentrationThe mixture was concentrated under reduced pressure
3. additiondiluted with EtOAc (200 mL)
4. washThe mixture was washed with brine (3×80 mL)
5. dry with materialthe organic layer was dried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure