Ammonium Hydroxide → 5-Iodo-4-methyl-1H-pyrazole-3-carboxamide

HRID 1488164Notes

Reaction equation

HRID 1488164 reaction equation
[I:1][C:2]1[NH:6][N:5]=[C:4]([C:7](OCC)=[O:8])[C:3]=1[CH3:12].[OH-].[NH4+:14]>CO>[I:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([NH2:14])=[O:8])[C:3]=1[CH3:12]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 90029656HCID 90029656, compound2×

Product 1

HCID 900301425-Iodo-4-methyl-1H-pyrazole-3-carboxamideYield 89%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

Into a 100-mL round-bottom flask, was placed a solution of ethyl 5-iodo-4-methyl-1H-pyrazole-3-carboxylate (compound 258.1, 500 mg, 1.79 mmol) in methanol (5 mL). Then ammonium hydroxide (15 mL, 25% aq.) was added and the resulting solution was stirred overnight at 60° C. The mixture was concentrated under reduced pressure to obtain the title compound as a white solid (400 mg, 89%).

Workup

  1. customInto a 100-mL round-bottom flask, was placed
  2. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-03a19117699a41d9bd57505bb7706270
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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