Hydrazine hydrate (1:1) → HCID 178430911, compound
Reaction equation
C(O/[CH:4]=[C:5](\[CH3:12])/[C:6](=O)[C:7]([F:10])([F:9])[F:8])C.O.[NH2:14][NH2:15]>CCO>[CH3:12][C:5]1[C:6]([C:7]([F:10])([F:9])[F:8])=[N:14][NH:15][CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
Into a 100-mL round-bottom flask, was placed (E)-4-ethoxy-1,1,1-trifluoro-3-methylbut-3-en-2-one (compound 261.1, 2.6 g, 14.3 mmol) in EtOH (20 mL). Hydrazine hydrate (1.8 mL, 38 mmol) was added and the resulting solution was stirred for 2 h at 80° C. The reaction was concentrated under reduced pressure to obtain the title compound as a yellow oil (2 g, crude).
Workup
- customInto a 100-mL round-bottom flask, was placed
- concentrationThe reaction was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-8ee4985915c64c7e9fd2fd372f022501
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09428502B2
Reaction notes
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