Acetic Acid Mixture with Hydrobromic Acid → HCID 178424692, compound

HRID 1488186Notes

Reaction equation

HRID 1488186 reaction equation
[Cl:1][C:2]1[C:3]([CH2:19]OC)=[N:4][NH:5][C:6]=1[C:7]1[C:8]([CH3:18])=[CH:9][C:10]([CH3:17])=[C:11]([CH:16]=1)[C:12]([O:14]C)=[O:13].[BrH:22].CC(O)=O>>[Br:22][CH2:19][C:3]1[C:2]([Cl:1])=[C:6]([C:7]2[C:8]([CH3:18])=[CH:9][C:10]([CH3:17])=[C:11]([CH:16]=2)[C:12]([OH:14])=[O:13])[NH:5][N:4]=1

Participants

3

Reactant 2

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 178494727HCID 178494727, compound2×

Product 1

HCID 178424692HCID 178424692, compoundYield 90%

Conditions

Temperature
80 °C

Procedure

A mixture of methyl 5-(4-chloro-3-(methoxymethyl)-1H-pyrazol-5-yl)-2,4-dimethylbenzoate (compound 281.3, 20 mg, 0.06 mmol) and HBr-HOAc (5 mL) was stirred overnight at 80° C., then concentrated under reduced pressure to yield 20 mg (90%) of the title compound as a yellow oil.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-4a6ba192ac89418bacdbed7145cc9d4d
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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