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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1488222Generated: November 3, 2026

Methyl 4-methyl-3-(2-(tetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1H-imidazol-5-yl)benzoate → HCID 178425885, compound

https://huagongshe.com/reaction/1488222

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-methyl-3-(2-(tetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1H-imidazol-5-yl)benzoateHCID 178497714—
SolventHydrochloric AcidHCID 313—
ProductHCID 178425885HCID 178425885—

Reaction Steps

A solution of methyl 4-methyl-3-(2-(tetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1H-imidazol-5-yl)benzoate (compound 287.2, 50 mg, 0.14 mmol) in HCl (6 M) (2 mL) was stirred for 5 h at 80° C., then concentrated under reduced pressure. This resulted 200 mg (crude) of the title compound as a brown solid which was used in the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09428502B2
Source datasetuspto-grants-2016_08
ORD IDord-38af5840291e4e54b6b14a3e41fa27a2
Source noteuspto-grants-2016_08