Methyl 4-methyl-3-(2-(tetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1H-imidazol-5-yl)benzoate → HCID 178425885, compound

HRID 1488222Notes

Reaction equation

HRID 1488222 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[C:12]1[NH:16][C:15]([CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[N:14][C:13]=1[C:23]([F:26])([F:25])[F:24]>Cl>[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[C:12]1[NH:16][C:15]([CH:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)=[N:14][C:13]=1[C:23]([F:25])([F:24])[F:26]

Participants

3

Reactant 1

HCID 178497714Methyl 4-methyl-3-(2-(tetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1H-imidazol-5-yl)benzoate2×

Product 1

HCID 178425885HCID 178425885, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of methyl 4-methyl-3-(2-(tetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)-1H-imidazol-5-yl)benzoate (compound 287.2, 50 mg, 0.14 mmol) in HCl (6 M) (2 mL) was stirred for 5 h at 80° C., then concentrated under reduced pressure. This resulted 200 mg (crude) of the title compound as a brown solid which was used in the next step without further purification.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThis resulted 200 mg (crude) of the title compound as a brown solid which was used in the next step without further purification

Sources & evidence

ORD record
ord-38af5840291e4e54b6b14a3e41fa27a2
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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