Hydrochloric Acid → HCID 178432806, compound

HRID 1488225Notes

Reaction equation

HRID 1488225 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[N:5]=[C:6]([CH3:15])[N:7](S(N(C)C)(=O)=O)[CH:8]=1.Cl>O1CCOCC1>[CH3:15][C:6]1[NH:7][CH:8]=[C:4]([CH2:3][CH2:2][OH:1])[N:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90066757HCID 90066757, compound2×

Product 1

HCID 178432806HCID 178432806, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
85 °C

Procedure

To a solution of 4-(2-hydroxyethyl)-N,N,2-trimethyl-1H-imidazole-1-sulfonamide (compound 282.2, 1 g, 4.29 mmol) in 1,4-dioxane (30 mL) was added HCl (6 M, 30 mL). The reaction mixture was stirred for 4 h at 85° C., then concentrated under reduced pressure. The pH of the solution was adjusted to 7-8 with NaHCO3 (sat.). The resulting mixture was concentrated under reduced pressure to afford 3 g (crude) of the title compound as a white solid.

Workup

  1. concentrationconcentrated under reduced pressure
  2. concentrationThe resulting mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-79e6f81b94cd482e9b9af81ecdfadc99
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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