HCID 178497712, compound → HCID 178425880, compound

HRID 1488230Notes

Reaction equation

HRID 1488230 reaction equation
C[O:2][CH:3]1[CH2:8][CH2:7][CH:6]([C:9]2[NH:10][C:11]([C:15]3[CH:16]=[C:17]([CH:22]=[CH:23][C:24]=3[CH3:25])[C:18]([O:20]C)=[O:19])=[C:12]([CH3:14])[N:13]=2)[CH2:5][CH2:4]1>I>[OH:2][CH:3]1[CH2:4][CH2:5][CH:6]([C:9]2[NH:10][C:11]([C:15]3[CH:16]=[C:17]([CH:22]=[CH:23][C:24]=3[CH3:25])[C:18]([OH:20])=[O:19])=[C:12]([CH3:14])[N:13]=2)[CH2:7][CH2:8]1

Participants

3

Reactant 1

HCID 178497712HCID 178497712, compound2×

Product 1

HCID 178425880HCID 178425880, compound

Reagents, catalysts & solvents 1

HCID 24841Hydrogen iodideSolvent

Procedure

A solution of methyl 3-(2-(4-methoxycyclohexyl)-4-methyl-1H-imidazol-5-yl)-4-methylbenzoate (compound 300.2, 300 mg, 0.88 mmol) in HI (45% in water) (3 mL) was stirred for 2 h at 60° C., then concentrated under reduced pressure. This resulted in 500 mg (crude) of the title compound as brown oil which was used into the next step without further purification.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c30e486f424e48d7b798adfb98ec2a5b
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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