Hydrochloric Acid → HCID 49853440, compound

HRID 1488296Notes

Reaction equation

HRID 1488296 reaction equation
C(OC([NH:8][CH2:9][C@H:10]([C:29]([OH:31])=[O:30])[NH:11][C:12]([O:14][CH2:15][CH:16]1[C:28]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:22]2[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:13])=O)(C)(C)C.[ClH:32]>C(Cl)Cl>[ClH:32].[NH2:8][CH2:9][C@@H:10]([C:29]([OH:31])=[O:30])[NH:11][C:12]([O:14][CH2:15][CH:16]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:22]=2[C:23]2[C:28]1=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 170401273-{[tert-Butoxy(hydroxy)methylidene]amino}-N-{[(9H-fluoren-9-yl)methoxy](hydroxy)methylidene}alanine

Product 1

HCID 49853440HCID 49853440, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 3-[(tert-butoxycarbonyl)amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-alanine (1.0 g, 2.35 mmol) in CH2Cl2 (11.72 mL) was added HCl (4.0 M in dioxane, 11.72 mL, 46.9 mmol). After stirring for 16 hours, the reaction mixture was concentrated to give the title product, which was used without further purification. LC-MS Method A: m/e=327.19 [M+1]; Rt=1.73 min.

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-680f161a68f94c5fba53614706ae2e4f
Source dataset
uspto-grants-2016_08
Patent number
US09427475B2

Reaction notes

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