反应详情

In a 500 ml two-neck flask, N-(t-butylphenyl) carbazolone (Compound F, 13 g) and diphenylether (100 ml) were mixed, and the 10% Pd/C (13 g) was added thereto. This reaction solution was refluxed and stirred for 30 minutes to 1 hour. When the reaction was completed, 80% of diphenylether was removed by distillation under reduced pressure, and a catalyst was removed using celite. The filtrate was washed again with ethylacetate. The filtrate was concentrated under reduced pressure and separated using a column chromatography, thereby obtaining 11 g of N-(t-butylphenyl)hydroxycarbazole (Compound G).

1. temperatureThis reaction solution was refluxed
2. custom80% of diphenylether was removed by distillation under reduced pressure
3. customa catalyst was removed
4. washThe filtrate was washed again with ethylacetate
5. concentrationThe filtrate was concentrated under reduced pressure
6. customseparated