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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1488335Generated: November 3, 2026

Diethyl Ether → p-(Benzyloxy)phenethyl alcohol

https://huagongshe.com/reaction/1488335

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl EtherHCID 3283—
ReactantBenzyl BromideHCID 7498—
ReactantTyrosolHCID 10393—
ReactantPotassium CarbonateHCID 11430—
SolventAcetoneHCID 180—
SolventWaterHCID 962—
Productp-(Benzyloxy)phenethyl alcoholHCID 3017260—

Reaction Steps

A mixture of 4-hydroxyphenethyl alcohol (15.02 g), benzyl bromide (13.6 ml), and potassium carbonate (75.1 g) in acetone (250 ml) is heated at reflux for about 4 hours. The mixture is cooled and poured into ether and water. The organic layer is washed with water, 1N sodium hydroxide solution, brine, dried over magnesium sulfate, filtered and concentrated in vacuo to give 4-benzyloxyphenethyl alcohol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05674482
Source datasetuspto-grants-1997_10
ORD IDord-b2691b85c0e342e2a1caeac5db949915
Source noteuspto-grants-1997_10