Pyrrole → HCID 135490566, compound

HRID 1488439Notes

Reaction equation

HRID 1488439 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH:8]=O)(=[O:3])[CH3:2].[NH:13]1[CH:17]=[CH:16][CH:15]=[CH:14]1>C(O)(=O)CC>[C:1]([NH:4][C:5]1[CH:6]=[C:7]([C:8]2[C:17]3[NH:13][C:14]([C:8]([C:7]4[CH:10]=[CH:11][CH:12]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:6]=4)=[C:14]4[N:13]=[C:17]([C:8]([C:7]5[CH:10]=[CH:11][CH:12]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:6]=5)=[C:14]5[NH:13][C:17](=[C:8]([C:7]6[CH:10]=[CH:11][CH:12]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:6]=6)[C:14]6[CH:15]=[CH:16][C:17]=2[N:13]=6)[CH:16]=[CH:15]5)[CH:16]=[CH:15]4)=[CH:15][CH:16]=3)[CH:10]=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 8027PyrroleHCID 256849N-(3-formylphenyl)acetamide

Product 1

HCID 135490566HCID 135490566, compound

Reagents, catalysts & solvents 1

HCID 1032Propionic AcidSolvent

Conditions

Temperature
60 °C

Procedure

16.32 g (0.10 mol) of 3-acetylaminobenzaldehyde (EMS-Dottikon AG) is dissolved in 300 ml of propionic acid and the solution is heated to 60° C. 6.71 g (0.10 mol) of pyrrole is instilled slowly and the dark solution is stirred for one hour at 110° C. After cooling, it is completely concentrated by evaporation in a vacuum, and the residue is recrystallized from pyridine/diethyl ether.

Workup

  1. temperatureAfter cooling
  2. concentrationit is completely concentrated by evaporation in a vacuum
  3. customthe residue is recrystallized from pyridine/diethyl ether

Sources & evidence

ORD record
ord-bb476ce3d97a49b8bb28d401cd14e72a
Source dataset
uspto-grants-1997_10
Patent number
US05674467

Reaction notes

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