m-Chloroperbenzoic acid → 5-Bromo-2-methoxyphenol

A solution of 5-bromo-2-methoxybenzaldehyde (100 g, 0.46 mol) in chloroform (250 ml) was cooled with an ice bath and 3-chloroperoxybenzoic acid (50-60% purity) (146 g, 0.51 mol) chloroform (1000 ml) added. The reaction mixture was allowed to warm slowly to room temperature and stirred for 72 h. The white solid was filtered off and the filtrate concentrated in vacuo. The residue was dissolved in ether (200 ml) and washed with 1M sodium sulphite solution (2×200 ml) then sodium hydrogen carbonate [half saturated] (3×200 ml). The ether layer was washed with 10% aqueous sodium hydroxide (3×100 ml) and the combined basic extract was acidified with concentrated hydrochloric acid and extracted with Et2O (3×100 ml). The combined organic extract was dried (MgSO4) and florisil (10 g) filtered and the solvent removed under reduced pressure to give the title compound (90 g) as a pale brown solid.

1. filtrationThe white solid was filtered off
2. concentrationthe filtrate concentrated in vacuo
3. dissolutionThe residue was dissolved in ether (200 ml)
4. washwashed with 1M sodium sulphite solution (2×200 ml)
5. washThe ether layer was washed with 10% aqueous sodium hydroxide (3×100 ml)
6. extractionthe combined basic extract
7. extractionextracted with Et2O (3×100 ml)
8. extractionThe combined organic extract
9. dry with materialwas dried (MgSO4) and florisil (10 g)
10. filtrationfiltered
11. customthe solvent removed under reduced pressure

ORD record

ord-0f02f31a123449f4964f7c0c1f1ac498

Source dataset

uspto-grants-1997_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05674880