Hydrochloric Acid → HCID 22905775, compound

HRID 1488500Notes

Reaction equation

HRID 1488500 reaction equation
CC(C)([O-])C.[K+].[NH2:7][N:8]1[CH:12]=[N:11][N:10]=[CH:9]1.F[C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=1.Cl>CS(C)=O>[F:21][C:20]([F:23])([F:22])[C:17]1[CH:18]=[CH:19][C:14]([NH:7][N:8]2[CH:12]=[N:11][N:10]=[CH:9]2)=[CH:15][CH:16]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 114324-Amino-1,2,4-triazoleHCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 23665647Potassium tert-butoxide

Product 1

HCID 22905775HCID 22905775, compoundYield 84.6%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

3.36 Grams of potassium tert-butoxide was added to 15 ml of anhydrous dimethylsulfoxide and the mixture was stirred for 30 minutes at room temperature. Next, 2.52 g of 4-amino-4H-1,2,4-triazole was added to the solution. After the reaction mixture was stirred for 15 minutes at room temperature, 1.64 g of 4-fluorobenzotrifluoride was added thereto and the mixture was stirred for further 30 minutes at room temperature. Ice-water was added to the reaction mixture, which was then neutralized with a diluted hydrochloric acid. The crystals as precipitated out were collected by filtration to give 1.93 g of 4-[(4-trifluoromethylphenyl)amino]-4H-1,2,4-triazole.

Workup

  1. stirringAfter the reaction mixture was stirred for 15 minutes at room temperature
  2. stirringthe mixture was stirred for further 30 minutes at room temperature
  3. customThe crystals as precipitated
  4. filtrationout were collected by filtration

Sources & evidence

ORD record
ord-ae04cb1b0cdc464785c0fad3bdfc3ab6
Source dataset
uspto-grants-1997_10
Patent number
US05674886

Reaction notes

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