Trifluoroacetic acid → HCID 178440668, compound

HRID 1488657Notes

Reaction equation

HRID 1488657 reaction equation
[CH2:1]([C:5]1[N:13]2[C:8]([C:9](=[CH:31][C:32]([O:34]C(C)(C)C)=[O:33])[CH2:10][CH2:11][CH:12]2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].C(O)(C(F)(F)F)=O>>[CH2:1]([C:5]1[N:13]2[C:8]([C:9](=[CH:31][C:32]([OH:34])=[O:33])[CH2:10][CH2:11][CH:12]2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:27][N:28]=[N:29][N:30]=3)=[CH:16][CH:15]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178440670HCID 178440670, compound

Product 1

HCID 178440668HCID 178440668, compound

Procedure

To a solution of unsaturated tert-butyl ester (0.0627 mmol, the title compound of Example 1947) in 2 mL of CDCl3 at room temperature is added 0.5 mL of TFA, and the progress of the reaction is monitored by 1H NMR. The resulting yellow solution is stirred at room temperature until the reaction is complete. The mixture is concentrated in vacuo. The crude product is purified to give the title compound of Example 1948.

Workup

  1. concentrationThe mixture is concentrated in vacuo
  2. customThe crude product is purified

Sources & evidence

ORD record
ord-6eefab4d195046fe86d829030ccaf84d
Source dataset
uspto-grants-1997_10
Patent number
US05674879

Reaction notes

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