Trifluoroacetic acid → HCID 178440669, compound

HRID 1488658Notes

Reaction equation

HRID 1488658 reaction equation
[CH2:1]([C:5]1[N:13]2[C:8]([C:9]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])=[CH:10][CH2:11][CH:12]2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].C(O)(C(F)(F)F)=O>C(Cl)(Cl)Cl>[CH2:1]([C:5]1[N:13]2[C:8]([C:9]([CH2:31][C:32]([OH:34])=[O:33])=[CH:10][CH2:11][CH:12]2[C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:27][N:28]=[N:29][N:30]=3)=[CH:16][CH:15]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178440671HCID 178440671, compound

Product 1

HCID 178440669HCID 178440669, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of biphenyl indolizinyl tert-butyl ester (0.039 mmol, the title compound of Example 1949) in 0.5 mL of chloroform is added 0.25 mL of TFA, and the progress of the reaction is monitored by 1H NMR. The resulting solution is stirred at room temperature until the reaction is complete. The mixture is quenched with methanol and concentrated in vacuo. The residue is purified to give the title compound of Example 1950.

Workup

  1. customThe mixture is quenched with methanol
  2. concentrationconcentrated in vacuo
  3. customThe residue is purified

Sources & evidence

ORD record
ord-3d7f3518f4fe440e9e0d3772bcb25725
Source dataset
uspto-grants-1997_10
Patent number
US05674879

Reaction notes

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