Hydrochloric Acid → HCID 70059846, compound

HRID 1488714Notes

Reaction equation

HRID 1488714 reaction equation
Cl.[O-:2][C:3]#[N:4].[Na+].[CH2:6]([NH:9][C@H:10]([CH:36]1[CH2:45][CH2:44][C:43]2[C:38](=[CH:39][CH:40]=[C:41]([O:54][CH2:55][C:56]3[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=3)[C:42]=2[O:46][CH2:47][C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[CH2:37]1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][N:16]([C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])[CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)[CH2:7][CH3:8]>ClC1C=CC=CC=1>[CH2:6]([NH:9][C@H:10]([CH:36]1[CH2:45][CH2:44][C:43]2[C:38](=[CH:39][CH:40]=[C:41]([O:54][CH2:55][C:56]3[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=3)[C:42]=2[O:46][CH2:47][C:48]2[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=2)[CH2:37]1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][N:16]([C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])[CH2:17][CH2:18][C:19]1[CH:20]=[CH:21][C:22]([NH:25][C:3]([NH2:4])=[O:2])=[CH:23][CH:24]=1)[CH2:7][CH3:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 517096Sodium CyanateHCID 53999664HCID 53999664, compound

Product 1

HCID 70059846HCID 70059846, compound

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

Concentrated HCl (0.7 g; 7.1 mmoles) and sodium cyanate (0.38 g; 5.8 mmoles) were added at room temperature to a stirred solution of Intermediate 64 (2.2 g; 2.9 mmoles), prepared as described in example 32, in chlorobenzene (20 ml) under nitrogen.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-d82d387ef16247519c379e7369322108
Source dataset
uspto-grants-1997_10
Patent number
US05674909

Reaction notes

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