1-(2-Bromoethoxy)-4-fluorobenzene → HCID 22903437, compound

HRID 1488955Notes

Reaction equation

HRID 1488955 reaction equation
[CH3:1][O:2][P:3]([CH2:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])([O:5][CH3:6])=[O:4].[F:15][C:16]1[CH:25]=[CH:24][C:19]([O:20][CH2:21][CH2:22]Br)=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:25]=[CH:24][C:19]([O:20][CH2:21][CH2:22][CH:7]([P:3]([O:5][CH3:6])([O:2][CH3:1])=[O:4])[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 20641711-(2-Bromoethoxy)-4-fluorobenzeneHCID 4564495tert-Butyl Dimethylphosphonoacetate

Product 1

HCID 22903437HCID 22903437, compoundYield 61.6%

Procedure

20.5 g of tert-butyl dimethylphosphonoacetate were reacted with 25 g of 4-fluorophenoxyethyl bromide by the method described in Example 5 A). The reaction mixture was worked up as described in Example 5 A). 20.4 g of tert-butyl 4-(4-fluorophenoxy)-2-(dimethylphosphono)-n-butyrate were obtained.

Sources & evidence

ORD record
ord-45d0f7d8b9bb42f59a1024bfc3f3b33d
Source dataset
uspto-grants-1997_10
Patent number
US05677297

Reaction notes

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