Potassium Hydroxide → HCID 22903581, compound

HRID 1488976Notes

Reaction equation

HRID 1488976 reaction equation
F[C:2]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:16])[C:8](=[O:15])[N:9]2[CH2:12][CH2:13][CH3:14])=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].[N+:20]([C:23]1[CH:24]=[N:25][CH:26]=[CH:27][C:28]=1[OH:29])([O-:22])=[O:21].[OH-].[K+]>CS(C)=O>[N+:17]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[N:25]1[CH:26]=[CH:27][C:28](=[O:29])[C:23]([N+:20]([O-:22])=[O:21])=[CH:24]1)[N:9]([CH2:12][CH2:13][CH3:14])[C:8](=[O:15])[C:7](=[O:16])[NH:6]2)([O-:19])=[O:18]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 22903589HCID 22903589, compoundHCID 178526806HCID 178526806, compound

Product 1

HCID 22903581HCID 22903581, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

First, 803 mg of 7-fluoro-6-nitro-1-(n-propyl)-1,4-dihydroquinoxaline-2,3-dione, 700 mg of 3-nitro-4-hydroxypyridine, and 365 mg of potassium hydroxide were allowed to react at 130° C. for 4.5 hours in dry dimethylsulfoxide in the same way as in Example 9 to give 1.059 g of 6-nitro-7-(3-nitro-4-oxo-4H-pyridin-1-yl)-1-(n-propyl)-1,4-dihydroquinoxaline-2,3-dione.

Sources & evidence

ORD record
ord-189ebdb7341d4c39b6742186d3465c5a
Source dataset
uspto-grants-1997_10
Patent number
US05677305

Reaction notes

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