Hydrochloric Acid → HCID 131720226, compound

HRID 1489015Notes

Reaction equation

HRID 1489015 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH:5]([N:12]1[CH:16]=[CH:15][N:14]=[C:13]1[C:17]([NH2:19])=[O:18])[C:6]2=O.[ClH:20]>CO>[ClH:20].[CH3:1][C:2]1[C:3]2[CH2:4][C:5]3[N:12]4[CH:16]=[CH:15][N:14]=[C:13]4[C:17](=[O:18])[NH:19][C:6]=3[C:7]=2[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22903611HCID 22903611, compound

Product 1

HCID 131720226HCID 131720226, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The procedure is carried out as in Example 1 but starting with 2 g of 1-(4-methyl-1-oxo-2-indanyl)imidazole-2-carboxamide, a total of 60 ml of methanol and 25 ml of 12N aqueous hydrochloric acid solution. 1.45 g of 9-methyl-5H, 10H-imidazo [1,2-a]indeno[1,2-e]pyrazin-4-one hydrochloride are thus obtained which decompose without melting above 300° C. [NMR spectrum: (300 MHz; DMSO-d6 plus a few drops of CD3COOD-d4 ; δ in ppm): 2.40 (s, 3H: --CH3); 4.01 (s, 2H: --CH2-- in position 10); 7.23 (d, J=8 Hz 1H: --H8); 7.36 (t, J=8 Hz, 1H: --H7); 7.8 (d, J=8 Hz, 1H: --H6); 8.17 and 8.36 (2d, J=1 Hz, 1H each: --H of imidazole).

Sources & evidence

ORD record
ord-01a6e85395804d0780fdcbd9c3827385
Source dataset
uspto-grants-1997_10
Patent number
US05677306

Reaction notes

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