Hydrochloric Acid → HCID 131720228, compound

HRID 1489020Notes

Reaction equation

HRID 1489020 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]3[C:12](=[CH:13][CH:14]=2)[C:11](=O)[CH:10]([N:16]2[CH:20]=[CH:19][N:18]=[C:17]2[C:21]([NH2:23])=[O:22])[CH2:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.[ClH:24]>CO>[ClH:24].[N:1]1([C:6]2[CH:14]=[CH:13][C:12]3[C:11]4[NH:23][C:21](=[O:22])[C:17]5[N:16]([CH:20]=[CH:19][N:18]=5)[C:10]=4[CH2:9][C:8]=3[CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22903638HCID 22903638, compound

Product 1

HCID 131720228HCID 131720228, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The procedure is carried out as in Example 1 but starting with 0.46 g of 1-[5-(1-imidazolyl)-1-oxo-2-indanyl]imidazole-2-carboxamide, a total of 35 ml of methanol and 7 ml of a 12N aqueous hydrochloric acid solution. 0.23 of 8-(1-imidazolyl)-5H, 10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one hydrochloride is thus obtained which decomposes without melting above 300° C. [NMR spectrum: (200 MHz; DMSO-d6 ; δ in ppm): 4.18 (s, 2H: --CH2-- in position 10); 7.71 and from 8.00 to 8.15 (broad s and mt respectively, 1H for the s: --H of imidazole); 7.88 (dd, J=8 and 2 Hz 1H: --H7); 7.96 and 8.34 (2 mt, 1H each: --H4' and --H5' of imidazole in position 8); 8.08 (d, J=8 Hz: --H6); from 8.00 to 8.15 (mt: --H9); 9.73 (broad s, 1H: --H2' of imidazole in position 8); 12.65 (unresolved complex, 1H: --CONH--)].

Sources & evidence

ORD record
ord-62ad4326be24434e92a509c802d93e02
Source dataset
uspto-grants-1997_10
Patent number
US05677306

Reaction notes

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