Methanol → HCID 70084054, compound

HRID 1489022Notes

Reaction equation

HRID 1489022 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][CH:7]([N:13]3[CH:17]=[CH:16][N:15]=[C:14]3[C:18]([NH2:20])=[O:19])[C:8]2=O)=[CH:4][CH:3]=1.CO>Cl>[Cl:11][C:10]1[C:9]2[C:8]3[NH:20][C:18](=[O:19])[C:14]4[N:13]([CH:17]=[CH:16][N:15]=4)[C:7]=3[CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[Cl:1]

Participants

4

Reactant 2

HCID 887MethanolHCID 229035981-(6,7-Dichloro-2,3-dihydro-1-oxo-1H-inden-2-yl)-1H-imidazole-2-carboxamide

Product 1

HCID 70084054HCID 70084054, compoundYield 39.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent2×

Procedure

The procedure is carried out as in Example 14 but starting with 0.26 g of 1-(6,7-dichloro-1-oxo-2-indanyl)imidazole-2-carboxamide, 80 ml of methanol and 20 ml of hydrochloric acid (12N). 97 mg of 6,7-dichloro-5H, 10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one are thus obtained in hydrochloride form which melt at a temperature greater than 260° C. (analysis: % calculated C: 49.35, H: 2.44, Cl: 29.88, N: 13.28, % found C: 49.40, H: 2.10, Cl: 29.90, N: 13.10).

Sources & evidence

ORD record
ord-7795227a42924cdbb3fdc490ee4297ee
Source dataset
uspto-grants-1997_10
Patent number
US05677306

Reaction notes

Loading…