反应详情

The 2-bromo-6,7-dichloro-1-indanone is prepared as in Example 14 for the preparation of 2-bromo-4-fluoro-1-indanone but starting with 7.42 g of 6,7-dichloro-1-indanone, 21.8 g of copper bromide and 240 ml of dioxane. After purification by silica column chromatography with an ethyl acetate-cyclohexane mixture (10-90 by volume) as eluent, 6.79 g of 2-bromo-6,7-dichloro-1-indanone are obtained which melt at 103° C.

1. customAfter purification by silica column chromatography with an ethyl acetate-cyclohexane mixture (10-90 by volume) as eluent