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HRID1489307

反应详情

EQUATION

反应方程式

HRID 1489307 的结构方程式

REACTANTS

反应物

4
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
HCID688217

FMOC-L-valine

C20H21NO4

结构：Nc1n[nH]c(=S)s1
HCID2723847

5-Amino-1,3,4-thiadiazole-2-thiol

C2H3N3S2

PRODUCTS

生成物

1
结构：CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)Nc1n[nH]c(=S)s1
HCID22878134

未命名化合物

PROCEDURE

实验过程

Fmoc-Valine (0.68 grams), 1-hydroxybenzotriazole (0.36 grams), dicyclohexylcarbodiimide (0.42 grams) and 5-amino-1,3,4-thiadiazole-2-thione (0.4 grams) were reacted according to the procedures described in Example 1. The resulting product was recrystallized from ethanol-pentane. M.P. 141°-144° C. NMR spectrum (d6 -DMSO) 14.06 (s, 1H), 12.56 (s,1H), 8.00-7.60;7.5-7.2 (m, 9H; NH+aromatics) 4.4-4.0 (m, 4H) 2.2-2.0 (m, 1H), 0.98 (bs, 6H).

WORKUP

后处理

  1. customThe resulting product was recrystallized from ethanol-pentane