HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → 5-(N-(9-fluorenylmethoxycarbonyl)valylamino)-1,3,4-thiadiazole-2-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | FMOC-L-valine | HCID 688217 | — |
| Reactant | 2-Amino-5-mercapto-1,3,4-thiadiazole | HCID 2723847 | — |
| Product | 5-(N-(9-fluorenylmethoxycarbonyl)valylamino)-1,3,4-thiadiazole-2-thione | HCID 22878134 | — |
Reaction Steps
Fmoc-Valine (0.68 grams), 1-hydroxybenzotriazole (0.36 grams), dicyclohexylcarbodiimide (0.42 grams) and 5-amino-1,3,4-thiadiazole-2-thione (0.4 grams) were reacted according to the procedures described in Example 1. The resulting product was recrystallized from ethanol-pentane. M.P. 141°-144° C. NMR spectrum (d6 -DMSO) 14.06 (s, 1H), 12.56 (s,1H), 8.00-7.60;7.5-7.2 (m, 9H; NH+aromatics) 4.4-4.0 (m, 4H) 2.2-2.0 (m, 1H), 0.98 (bs, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05677282 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-4904cd000eab4f4caee6c90da1a0a0d6 |
| Source note | uspto-grants-1997_10 |