huagongshe.com
HRID1489309

反应详情

EQUATION

反应方程式

HRID 1489309 的结构方程式

REACTANTS

反应物

4
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：Nc1n[nH]c(=S)s1
HCID2723847

5-Amino-1,3,4-thiadiazole-2-thiol

C2H3N3S2

结构：CC(C)[C@H](NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)O
HCID54161085

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[C@H](NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)Nc1n[nH]c(=S)s1
HCID22878132

未命名化合物

PROCEDURE

实验过程

((4-Phenyl)phenylacetyl)-valine (0.98 grams), 1-hydroxybenzotriazole (0.6 grams), dicyclohexylcarbodiimide (0.64 grams) and 5-amino-1,3,4-thiadiazole-2-thione (1.2 grams) were reacted according to the procedure described in Example 1. The resulting product was recrystallized from ethanol/pentane to give a white solid. M.P. 232°-236° C. NMR spectrum (d6 -DMSO) 14.1 (s, 1H), 12.6 (s, 1H), 8.42 (d, 1H, NH), 7.8-7.2 (m, 9H, aromatics), 4.35 (m, 1H), 3.75-3.4 (m, 2H), 2.05 (m, 1H), 0.9 (d, 6H).

WORKUP

后处理

  1. customThe resulting product was recrystallized from ethanol/pentane
  2. customto give a white solid