HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → 5-(N-((4-phenyl)phenylacetyl) valylamino)-1,3,4-thiadiazole-2-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 2-Amino-5-mercapto-1,3,4-thiadiazole | HCID 2723847 | — |
| Reactant | ((4-Phenyl)phenylacetyl)-valine | HCID 54161085 | — |
| Product | 5-(N-((4-phenyl)phenylacetyl) valylamino)-1,3,4-thiadiazole-2-thione | HCID 22878132 | — |
Reaction Steps
((4-Phenyl)phenylacetyl)-valine (0.98 grams), 1-hydroxybenzotriazole (0.6 grams), dicyclohexylcarbodiimide (0.64 grams) and 5-amino-1,3,4-thiadiazole-2-thione (1.2 grams) were reacted according to the procedure described in Example 1. The resulting product was recrystallized from ethanol/pentane to give a white solid. M.P. 232°-236° C. NMR spectrum (d6 -DMSO) 14.1 (s, 1H), 12.6 (s, 1H), 8.42 (d, 1H, NH), 7.8-7.2 (m, 9H, aromatics), 4.35 (m, 1H), 3.75-3.4 (m, 2H), 2.05 (m, 1H), 0.9 (d, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05677282 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-bac93833687d4fd3a34e4d0c071d5268 |
| Source note | uspto-grants-1997_10 |