HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 10043561, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | ((2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate | HCID 7302460 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 10043561 | HCID 10043561 | 90% |
Reaction Steps
To a stirred solution of the thymidine tosylate (10.65 g, 26.9 mmol) prepared according to the method of Example 23 in dry acetone (75 ml) was added sodium iodide (10 g, 66.7 mmol) and the mixture refluxed for 16 hours. The solvent was evaporated and diluted with ethyl acetate. The organic phase was washed with water (2×20 ml) and brine (10 ml) and dried with sodium sulfate. The title compound was crystallized from methanol as a white crystalline solid in 90-95% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05677439 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-fe75f61d1e0d43f5a230a5f391aa57ae |
| Source note | uspto-grants-1997_10 |