反应详情

To a stirred solution of the thymidine tosylate (10.65 g, 26.9 mmol) prepared according to the method of Example 23 in dry acetone (75 ml) was added sodium iodide (10 g, 66.7 mmol) and the mixture refluxed for 16 hours. The solvent was evaporated and diluted with ethyl acetate. The organic phase was washed with water (2×20 ml) and brine (10 ml) and dried with sodium sulfate. The title compound was crystallized from methanol as a white crystalline solid in 90-95% yield.

1. temperaturethe mixture refluxed for 16 hours
2. customThe solvent was evaporated
3. additiondiluted with ethyl acetate
4. washThe organic phase was washed with water (2×20 ml) and brine (10 ml)
5. dry with materialdried with sodium sulfate
6. customThe title compound was crystallized from methanol as a white crystalline solid in 90-95% yield