Sodium Chloride → HCID 53902487, compound

Participants

Reaction Steps

12.6 g of 2,3-dihydro-3,4-dimethyl-2-oxo-1-pyrid-3-ylmethyleneamino-1H-imidazole hydrochloride are dissolved in 150 ml of water. The solution is saturated with sodium chloride and treated with 100 ml of tetrahydrofuran. The mixture is then rendered weakly alkaline using aqueous sodium hydroxide solution (30%). The phases are separated, and the aqueous phase is extracted nine times using in each case 100 ml of tetrahydrofuran. The combined tetrahydrofuran phases are dried using magnesium sulfate and evaporated, yielding the rifle compound in the form of yellow crystals melting at 186°-187°.

Provenance & Evidence