Sodium Chloride → HCID 53902487, compound

HRID 1489509Notes

Reaction equation

HRID 1489509 reaction equation
Cl.[CH3:2][N:3]1[C:7]([CH3:8])=[CH:6][N:5]([N:9]=[CH:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[C:4]1=[O:17].[Cl-].[Na+].O1CCCC1.[OH-].[Na+]>O>[CH3:2][N:3]1[C:7]([CH3:8])=[CH:6][N:5]([N:9]=[CH:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[C:4]1=[O:17]

Participants

6

Reactant 4

HCID 5234Sodium ChlorideHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 70340815HCID 70340815, compound

Product 1

HCID 53902487HCID 53902487, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

12.6 g of 2,3-dihydro-3,4-dimethyl-2-oxo-1-pyrid-3-ylmethyleneamino-1H-imidazole hydrochloride are dissolved in 150 ml of water. The solution is saturated with sodium chloride and treated with 100 ml of tetrahydrofuran. The mixture is then rendered weakly alkaline using aqueous sodium hydroxide solution (30%). The phases are separated, and the aqueous phase is extracted nine times using in each case 100 ml of tetrahydrofuran. The combined tetrahydrofuran phases are dried using magnesium sulfate and evaporated, yielding the rifle compound in the form of yellow crystals melting at 186°-187°.

Workup

  1. customThe phases are separated
  2. extractionthe aqueous phase is extracted nine times
  3. dry with materialThe combined tetrahydrofuran phases are dried
  4. customevaporated

Sources & evidence

ORD record
ord-0b7c256315a6477281794260b5d07ecd
Source dataset
uspto-grants-1997_10
Patent number
US05679623

Reaction notes

Loading…