Triethylamine → HCID 22902165, compound

HRID 1489539Notes

Reaction equation

HRID 1489539 reaction equation
[C:1]([NH:5][CH3:6])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[Cl:14][CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>ClCCl>[C:1]([N:5]([CH3:6])[S:18]([CH2:17][CH2:16][CH2:15][Cl:14])(=[O:20])=[O:19])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 154103-Chloropropanesulphonyl chlorideHCID 84552N-Methyl-tert-butylamine

Product 1

HCID 22902165HCID 22902165, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

1.74 g(0.02 mol) of t-butylmethylamine and 2 equivalents of triethylamine were dissolved in 100 ml of dichloromethane, which was stirred at 0° C. 3.54 g(0.02 mol) of 3-chloropropane sulfonyl chloride dissolved in 50 ml. of dichloromethane was added dropwise and the mixture was stirred for 1 hour at room temperature. The organic layer was washed with 1N HCl aqueous solution and dried over MgSO4 to obtain 3.31 g of the title compound(yield 73%).

Workup

  1. stirringthe mixture was stirred for 1 hour at room temperature
  2. washThe organic layer was washed with 1N HCl aqueous solution
  3. dry with materialdried over MgSO4

Sources & evidence

ORD record
ord-8eab1a3579404059bab5076a1408fc45
Source dataset
uspto-grants-1997_10
Patent number
US05679687

Reaction notes

Loading…