HCID 22878419, compound → HCID 67726058, compound

Participants

Reaction Steps

217 mg (0.5 mmol) of 7-[(3aS,7aR)3a-amino-1,2,3,7a-tetrahydro-isoindol-2-yl]-8-chloro-1-[(1R,2S)-2-fluorocyclopropyl]-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid are dissolved in a mixture of 5 ml of water and 0.5 ml of 1n hydrochloric acid. The solution is lyophilised. 7-[(3aS,7aR)3a-amino-1,2,3,7a-tetrahydro-isoindol-2-yl]-8-chloro-1-[(1R,2S)-2-fluorocyclopropyl]-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride is isolated in quantitative yield.

Provenance & Evidence