HCID 22878419, compound → HCID 67726058, compound

HRID 1489551Notes

Reaction equation

HRID 1489551 reaction equation
[NH2:1][C@@:2]12[CH:10]=[CH:9][CH:8]=[CH:7][C@@H:6]1[CH2:5][N:4]([C:11]1[C:20]([Cl:21])=[C:19]3[C:14]([C:15](=[O:29])[C:16]([C:26]([OH:28])=[O:27])=[CH:17][N:18]3[C@@H:22]3[CH2:24][C@@H:23]3[F:25])=[CH:13][C:12]=1[F:30])[CH2:3]2>O.Cl>[ClH:21].[NH2:1][C@@:2]12[CH:10]=[CH:9][CH:8]=[CH:7][C@@H:6]1[CH2:5][N:4]([C:11]1[C:20]([Cl:21])=[C:19]3[C:14]([C:15](=[O:29])[C:16]([C:26]([OH:28])=[O:27])=[CH:17][N:18]3[C@@H:22]3[CH2:24][C@@H:23]3[F:25])=[CH:13][C:12]=1[F:30])[CH2:3]2

Participants

4

Reactant 1

HCID 22878419HCID 22878419, compound

Product 1

HCID 67726058HCID 67726058, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

217 mg (0.5 mmol) of 7-[(3aS,7aR)3a-amino-1,2,3,7a-tetrahydro-isoindol-2-yl]-8-chloro-1-[(1R,2S)-2-fluorocyclopropyl]-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid are dissolved in a mixture of 5 ml of water and 0.5 ml of 1n hydrochloric acid. The solution is lyophilised. 7-[(3aS,7aR)3a-amino-1,2,3,7a-tetrahydro-isoindol-2-yl]-8-chloro-1-[(1R,2S)-2-fluorocyclopropyl]-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride is isolated in quantitative yield.

Sources & evidence

ORD record
ord-3f5b17d1198e4d79b2cef5c37a938c5a
Source dataset
uspto-grants-1997_10
Patent number
US05679689

Reaction notes

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