Sodium Hydroxide → HCID 23669088, compound

HRID 1489784Notes

Reaction equation

HRID 1489784 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([C:8]([CH3:13])([CH3:12])[C:9]([OH:11])=[O:10])[CH2:5][CH2:6][OH:7].[OH-].[Na+:15]>O>[OH:1][CH2:2][CH2:3][N:4]([C:8]([CH3:13])([CH3:12])[C:9]([O-:11])=[O:10])[CH2:5][CH2:6][OH:7].[Na+:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10198016HCID 10198016, compound

Product 1

HCID 23669088HCID 23669088, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-[N,N-bis-(2-hydroxyethyl)amino]-2-methylpropanoic acid (423.46 grams, 2.21 moles) (this material is about 99% pure; it contains 1% H2O) is added with stirring to a cooled solution of pure sodium hydroxide (88.57 grams, 2.21 moles) in pyrogen-free distilled water (400 ml.). The mixture is stirred until solution is effected. After reaching room temperature, the solution is stirred while enough pyrogen-free distilled water is added to make the total volume 1,000 ml. The solution is sterilized by filtration. This solution contains 47.4% by weight of, or is 2.21 molar in, sodium 2-[N,N-bis-(2-hydroxyethyl)-amino]-2-methylpropanoate.

Workup

  1. additionis added
  2. distillationin pyrogen-free distilled water (400 ml.)
  3. customAfter reaching room temperature
  4. stirringthe solution is stirred while enough
  5. distillationpyrogen-free distilled water
  6. additionis added
  7. filtrationThe solution is sterilized by filtration

Sources & evidence

ORD record
ord-184d7baa68bc4fd68a060335381a7b5a
Source dataset
uspto-grants-1997_10
Patent number
US05679711

Reaction notes

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