Chloromethyl Methyl Ether → HCID 131719456, compound

3.14 g of Compound (6) obtained in the step (a) and 6.7 ml of diisopropylethylamine were dissolved in 40 ml of dry dichloromethane solution. 2.33 g of chloromethylmethyl ether was added to the above mixture under ice-cooling and the reaction mixture was stirred for 1 hour under the same condition and for 15 hours at room temperature. After the reaction, the reaction mixture was washed with water, saturated sodium bicarbonate solution and saturated saline solution, and dried over magnesium sulfate. After removal of the solvent, the resulting residue was purified by silica gel column chromatography (chloroform-ethyl acetate) to give 1.42 g (36%) of 4(R)-methoxy-methyloxymethyl-2-methylthio-1,3-thiazoline [Compound (7)].

1. temperaturecooling
2. customAfter the reaction
3. washthe reaction mixture was washed with water, saturated sodium bicarbonate solution and saturated saline solution
4. dry with materialdried over magnesium sulfate
5. customAfter removal of the solvent
6. customthe resulting residue was purified by silica gel column chromatography (chloroform-ethyl acetate)

ORD record

ord-bf0e263b6aa645f19496e8d905f9a33e

Source dataset

uspto-grants-1997_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05679790