HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1489926Generated: October 31, 2026
4-Hydroxybenzaldehyde → Bisdemethoxycurcumin
https://huagongshe.com/reaction/1489926
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | Triethyl borate | HCID 9009 | — |
| Reactant | Acetylacetone | HCID 31261 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | Boron monoxide | HCID 6327189 | — |
| Product | Bisdemethoxycurcumin | HCID 5315472 | — |
Reaction Steps
A 1 L reactor was charged with 171 g of 4-hydroxybenzaldehyde, 46.6 g boron oxide, 300 g N,N-dimethylacetamide, 70.2 g 2,4-pentanedione and 145.5 g triethyl borate. The mixture was stirred and heated to a temperature of 80° C. under nitrogen. n-Butylamine totaling 21.3 g was then fed dropwise into the reaction mixture over a period of 60 minutes. The temperature of the reaction mixture varied between 80° and 85° C. during this period.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05679864 |
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| Source dataset | uspto-grants-1997_10 |
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| ORD ID | ord-bf1964674d5b4fdfb295228a8b830243 |
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| Source note | uspto-grants-1997_10 |
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